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InFact - Functional materials for fast diagnosis of wound infection


 

Project Budget: 3,950,000

Coordinator: Prof. Georg Guebitz, BOKU

The Need: Infection is a global problem of traumatic, post surgical or chronic wounds. For example 10% of surgical wounds exhibit bacterial infection within 30 days. Heavy bacteria colonization is the main reason for non-healing of chronic wounds such as decubitus, ulcus cruris and diabetic foot ulcers. The severity and cost of wound infections increase dramatically (>5 billion € per year in Europe) the longer they remain untreated. The resulting pain, impairment and social isolation lead to reduced quality of life and in the worst case lead to hospitalization, and eventually sepsis and death[1].

Early detection of an incipient wound infection is a challenge for the attending physician[2],[3] since its early diagnosis allows the timely initiation of treatment, thus reducing the severity of the disease[4]. Currently, however, wound infection is not diagnosed until becoming already evident. As a consequence, the treatment of the patient is further complicated and more likely to have a negative outcome4. Often wounds are treated with antibiotics before even the infection appears, leading to overdoses and development of bacterial resistance to antibiotics.

InFact rationale: Considering that optimal efficiency is reached when a material serves multiple functions without compromise, consortium partners have discovered the means to convert wound dressings into a diagnostic tool capable to inform both patient and therapist about the wound status, thus directing towards the following therapeutic step. The proposed functional materials include a real time diagnostic reaction that positively influences the wound healing due to the timely intervention to treat infection or proteolytic stasis in the wound. A next-generation of protective, predictive and proactive (triple-P) wound dressing materials will be prototyped and commercialized.

Beneficiary name

Country

University of Natural Resources and Life Sciences, Vienna

AT

Medical Spectrum Twente

NL

Qualizyme  Biotechnology

DE

Bar-Ilan University

IL

DAVO STAR

RO

TECMINHO

PT

Universitat Politècnica de Catalunya

ES

Synovo GmbH

DE

ConvaTec Ltd.

UK

TNO

NL

OSM-DAN Ltd.

IL



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